Endocrine Abstracts

Background: Although primary hyperparathyroidism (PHPT) has been associated with diabetes mellitus (DM), the etiological link is not clear and the effect of parathyroidectomy is controversial.The aim of this observational study was to investigate the metabolic link between calciotropic hormones and glucose metabolism in PHPT patients before and after parathyroidectomy.Methods: Twenty-four consecutive patients with PHPT (Group-A) without DM were included ...

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

Radioiodine treatment is the cornerstone of differentiated thyroid cancer (DTC) management. A number of thyroid cancers, however, become radioiodine-refractory (RAIR) and these represent about 60% of advanced DTCs and are responsible for the vast majority of DTC mortality. RAIR DTC has limited therapeutic options, mainly tyrosine kinase inhibitors that are associated with moderate efficacy and considerable toxicity. Reinducing NIS expression (redifferentiation) with the aim of...

Background: Primary hyperparathyroidism (PHPT) has been linked to glucose homeostasis disorders, leading to insulin resistance and type 2 diabetes mellitus. Previous small studies evaluating the effect of parathyroidectomy (PTX) on various parameters of glucose metabolism have produced conflicting results. The impact of PTX on incretin hormone levels has not been studied yet. The aim of this pilot study was to investigate the effect of PTX on markers of glucose metabolism and ...

Background: An increasing number of mutations are associated with pheochromocytomas. Genetic screening is advocated in all cases and immunohistochemistry as well as phenotype profile recognition may permit a more targeted screening for specific genes.Case Presentation: A 54-year-old male presented with symptoms compatible with pheochromocytoma and increased levels of plasma normetanephrines, metanephrines and 3-methoxytyramine. On Computed Tomography, th...